Patients and methods: Using a screening assay based on a combination of single-strand conformation polymorphism, denaturing high-performance liquid chromatography and sequence analysis, 47 Sardinian families with three or more BC cases were screened for germline mutations in BRCA1 and BRCA2 genes.
Background: The Sardinian population is genetically homogeneous and could be useful in understanding better the genetics of a complex disease like breast cancer (BC).
BRCA1 and BRCA2 germline mutations in Sardinian breast cancer families and their implications for genetic counseling
Palmieri G;Palomba G;Pisano M;
2002
Abstract
Background: The Sardinian population is genetically homogeneous and could be useful in understanding better the genetics of a complex disease like breast cancer (BC).File in questo prodotto:
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