We investigated molecular basis of hemoglobinopathies and RFLP haplotypes in 58 unrelated Albanian patients. A wide heterogeneity was detected characterized by 11 beta-thalassemia, 3 Hb variants and 4 alpha -globin alleles. All beta -thalassemia and Hb variant alleles were associated with the same haplotypes described in other populations. Genotype-phenotype correlation was established.
Beta- and alpha-globin genotypes in Albanian patients affected by beta globin gene disorders
Lacerra G;
2002
Abstract
We investigated molecular basis of hemoglobinopathies and RFLP haplotypes in 58 unrelated Albanian patients. A wide heterogeneity was detected characterized by 11 beta-thalassemia, 3 Hb variants and 4 alpha -globin alleles. All beta -thalassemia and Hb variant alleles were associated with the same haplotypes described in other populations. Genotype-phenotype correlation was established.File in questo prodotto:
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