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We present an algorithm, and its MATLAB implementation, based on mathematical methods to detect and localize 3D multicolor DNA FISH spots in fluorescence cell image z-stacks. This algorithm provides a method to measure the relative positioning of spots in the nucleus and inter-spot distances with the aim to enrich our understanding of the 3D spatial organization of the genome within the cell nucleus.

An algorithm for the analysis of the 3d spatial organization of the genome

Gregoretti Francesco;Oliva Gennaro;Antonelli Laura
2021

Abstract

We present an algorithm, and its MATLAB implementation, based on mathematical methods to detect and localize 3D multicolor DNA FISH spots in fluorescence cell image z-stacks. This algorithm provides a method to measure the relative positioning of spots in the nucleus and inter-spot distances with the aim to enrich our understanding of the 3D spatial organization of the genome within the cell nucleus.
2021
Istituto di Calcolo e Reti ad Alte Prestazioni - ICAR
Inglese
Bodega Beatrice; Lanzuolo Chiara
Capturing Chromosome Conformation
299
320
978-1-0716-0664-3
http://www.scopus.com/record/display.url?eid=2-s2.0-85090295474&origin=inward
Humana Press Inc.
Totowa
STATI UNITI D'AMERICA
Cellular and subcellular segmentation
Fluorescence microscopy
Image processing and analysis
Mathematical morphology method
Multicolor 3D-FISH
Nuclear organization
Variational segmentation model
2-s2.0-85090295474
WOS:000684273600018
5
02 Contributo in Volume::02.01 Contributo in volume (Capitolo o Saggio)
268
none
Gregoretti, Francesco; Cortesi, Alice; Oliva, Gennaro; Bodega, Beatrice; Antonelli, Laura
info:eu-repo/semantics/bookPart
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/378477
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