Objective: To identify the cellular mechanisms underlying impaired recent memories and intact remote memories in a mouse model of AD.

Background: Clinical evidence indicates that patients affected by Alzheimer's Disease (AD) fail to form new memories although their memories for old events are intact. This amnesic pattern depends on the selective vulnerability to AD-neurodegeneration of the hippocampus, the brain region that sustains the formation of new memories, while cortical regions that store remote memories are spared.

Synaptic Correlates of Anterograde Amnesia and Intact Retrograde Memory in a Mouse Model of Alzheimer's Disease

Middei Silvia;
2020

Abstract

Background: Clinical evidence indicates that patients affected by Alzheimer's Disease (AD) fail to form new memories although their memories for old events are intact. This amnesic pattern depends on the selective vulnerability to AD-neurodegeneration of the hippocampus, the brain region that sustains the formation of new memories, while cortical regions that store remote memories are spared.
2020
Objective: To identify the cellular mechanisms underlying impaired recent memories and intact remote memories in a mouse model of AD.
Alzheimer's disease
recent memory
remote memory
hippocampus
anterior cingulate cortex
synaptic plasticity
AMPA
NMDA
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/378757
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