Epigenetic reprogramming is emerging as a key mechanism for metastasis development.Our study identifed a novel regulatory mechanism whereby promoter methylation-mediated epigenetic silencing of the gene encoding the ubiquitin ligase subunit F-box/LRR-repeat protein 7 (FBXL7) induces accumulation of active c-SRC, which, in turn, activates epithelial-to-mesenchymal transition and supports cancer cell invasion and metastasis.
Epigenetic suppression of FBXL7 promotes metastasis
Loredana Moro;
2020
Abstract
Epigenetic reprogramming is emerging as a key mechanism for metastasis development.Our study identifed a novel regulatory mechanism whereby promoter methylation-mediated epigenetic silencing of the gene encoding the ubiquitin ligase subunit F-box/LRR-repeat protein 7 (FBXL7) induces accumulation of active c-SRC, which, in turn, activates epithelial-to-mesenchymal transition and supports cancer cell invasion and metastasis.File in questo prodotto:
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