Brown adipose tissue lipid metabolism in morbid obesity: Effect of bariatric surgery-induced weight loss

Materials and methods: A total of 23 morbidly obese women (BMI, 42.1 +/- 4.2 kg/m(2); age, 43.8 +/- 9.8 years) were assessed before and 6 months after bariatric surgery and 15 age-and sex-matched controls (22.6 +/- 2.8 kg/m(2)) were assessed once. In the supraclavicular fat depot, fractional (FUR) and NEFA uptake rates were measured with F-18-FTHA-PET. We assessed tissue morphology (triglyceride content) using computed tomography (CT)-radiodensity (in Hounsfield Units[HU]) and the proportion of fat with high density (sBAT [%]) in the entire supraclavicular fat depot.

Objective: We aimed to investigate the effect of bariatric surgery on lipid metabolism in supraclavicular brown adipose tissue in morbidly obese women. We hypothesized that lipid metabolism improves after surgery-induced weight loss.