MethodsWe sequentially measured serum intact FGF23 and carboxyl-terminal (iFGF23, cFGF23), the iFGF23/cFGF23 ratio, Klotho, biomarkers of inflammation (hs-CRP, IL-6 and TNF-) and sepsis (procalcitonin), nitrotyrosine (reflecting NO synthesis and oxidative stress), serum iron and ferritin and CKD-MBD biomarkers, PTH, 25(OH)VD, 1,25(OH)(2)VD at peak of intercurrent sepsis and after complete resolution in a series of 17 patients with CKD.
BackgroundHigh FGF23 and low -Klotho levels associate with systemic inflammation and reduced nitric oxide (NO) bioavailability, but the dynamics of this relationship in patients with CKD has not been investigated.
Intact FGF23 and -klotho during acute inflammation/sepsis in CKD patients
Torino Claudia;Pizzini Patrizia;Cutrupi Sebastiano;D'Arrigo Graziella;Tripepi Giovanni;
2017
Abstract
BackgroundHigh FGF23 and low -Klotho levels associate with systemic inflammation and reduced nitric oxide (NO) bioavailability, but the dynamics of this relationship in patients with CKD has not been investigated.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.