Intact FGF23 and -klotho during acute inflammation/sepsis in CKD patients

MethodsWe sequentially measured serum intact FGF23 and carboxyl-terminal (iFGF23, cFGF23), the iFGF23/cFGF23 ratio, Klotho, biomarkers of inflammation (hs-CRP, IL-6 and TNF-) and sepsis (procalcitonin), nitrotyrosine (reflecting NO synthesis and oxidative stress), serum iron and ferritin and CKD-MBD biomarkers, PTH, 25(OH)VD, 1,25(OH)(2)VD at peak of intercurrent sepsis and after complete resolution in a series of 17 patients with CKD.

BackgroundHigh FGF23 and low -Klotho levels associate with systemic inflammation and reduced nitric oxide (NO) bioavailability, but the dynamics of this relationship in patients with CKD has not been investigated.