MethodsWe sequentially measured serum intact FGF23 and carboxyl-terminal (iFGF23, cFGF23), the iFGF23/cFGF23 ratio, Klotho, biomarkers of inflammation (hs-CRP, IL-6 and TNF-) and sepsis (procalcitonin), nitrotyrosine (reflecting NO synthesis and oxidative stress), serum iron and ferritin and CKD-MBD biomarkers, PTH, 25(OH)VD, 1,25(OH)(2)VD at peak of intercurrent sepsis and after complete resolution in a series of 17 patients with CKD.
BackgroundHigh FGF23 and low -Klotho levels associate with systemic inflammation and reduced nitric oxide (NO) bioavailability, but the dynamics of this relationship in patients with CKD has not been investigated.
Intact FGF23 and -klotho during acute inflammation/sepsis in CKD patients
Torino Claudia;Pizzini Patrizia;Cutrupi Sebastiano;D'Arrigo Graziella;Tripepi Giovanni;
2017
Abstract
BackgroundHigh FGF23 and low -Klotho levels associate with systemic inflammation and reduced nitric oxide (NO) bioavailability, but the dynamics of this relationship in patients with CKD has not been investigated.| File | Dimensione | Formato | |
|---|---|---|---|
|
prod_431777-doc_174019.pdf
solo utenti autorizzati
Descrizione: KLOTHO 2017
Tipologia:
Versione Editoriale (PDF)
Dimensione
299.05 kB
Formato
Adobe PDF
|
299.05 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
