Design, fabrication and evaluation of nanoscale surface topography as a tool in directing differentiation and organisation of embryonic stem-cell-derived neural precursors

Recent in vitro research findings suggest that biomaterials with nanoscale surface topography can influence cell behaviour like adhesion, proliferation and differentiation. Therefore, the identification of biomaterials that support appropriate ES cell attachment, proliferation and differentiation into cells of interest is an attractive strategy worth investigation.

A major limitation in the translation of stem cells technology to clinical applications is the lack of efficient control over their proliferation and differentiation.