The object of this study is to develop novel self-assembled lyotropic liquid crystalline nanoparticles (hexosomes) as a natural delivery system based exclusively on Phosphatidilcoline and Cholesterol. Hexosomes are produced without the presence of a stabilizer using a mixture 20mg of Cholesterol and 66mg of Phosphatidylcholine in 10 ml formulation. TEM analysis and Small angle X-ray (SAXS) diffraction profiles confirm the presence of the hexagonal phase only in the tested samples. Hexosomes loaded with 1% w/w curcumin (0.086 mg/ml formulation) are prepared and represent a very high concentration of loaded drug, when compared with the value of 0.015% w/w previously reported in the literature for cubosome lyotropic liquid crystalline systems. Release studies conducted at pH 1.2 demonstrated that the developed hexosomes are able to achieve a "sustained release". The developed new hexosomes suggest a potential application not only limited as drug carriers, but suitable also for food, dietary supplements and cosmetic formulations, being both cholesterol and phosphatidylcholine food ingredients.
The object of this study is to develop novel self-assembled lyotropic liquid crystalline nanoparticles (hexosomes) as a natural delivery system based exclusively on Phosphatidilcoline and Cholesterol. Hexosomes are produced without the presence of a stabilizer using a mixture 20mg of Cholesterol and 66mg of Phosphatidylcholine in 10 ml formulation. TEM analysis and Small angle X-ray (SAXS) diffraction profiles confirm the presence of the hexagonal phase only in the tested samples. Hexosomes loaded with 1% w/w curcumin (0.086 mg/ml formulation) are prepared and represent a very high concentration of loaded drug, when compared with the value of 0.015% w/w previously reported in the literature for cubosome lyotropic liquid crystalline systems. Release studies conducted at pH 1.2 demonstrated that the developed hexosomes are able to achieve a "sustained release". The developed new hexosomes suggest a potential application not only limited as drug carriers, but suitable also for food, dietary supplements and cosmetic formulations, being both cholesterol and phosphatidylcholine food ingredients.
Hexosomes based on cholesterol and phosphatidylcholine: a new drug delivery system for curcumin release
Salvatici M C;
2015
Abstract
The object of this study is to develop novel self-assembled lyotropic liquid crystalline nanoparticles (hexosomes) as a natural delivery system based exclusively on Phosphatidilcoline and Cholesterol. Hexosomes are produced without the presence of a stabilizer using a mixture 20mg of Cholesterol and 66mg of Phosphatidylcholine in 10 ml formulation. TEM analysis and Small angle X-ray (SAXS) diffraction profiles confirm the presence of the hexagonal phase only in the tested samples. Hexosomes loaded with 1% w/w curcumin (0.086 mg/ml formulation) are prepared and represent a very high concentration of loaded drug, when compared with the value of 0.015% w/w previously reported in the literature for cubosome lyotropic liquid crystalline systems. Release studies conducted at pH 1.2 demonstrated that the developed hexosomes are able to achieve a "sustained release". The developed new hexosomes suggest a potential application not only limited as drug carriers, but suitable also for food, dietary supplements and cosmetic formulations, being both cholesterol and phosphatidylcholine food ingredients.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
