The development of functional supramolecular polymers, that readily self-assemble in aqueous media into structurally stable nanoconstructs with high drug loading capacity and controlled drug release ability under different environmental conditions, has recently attracted considerable attention as an efficient strategy to improve the efficiency of current drug delivery systems.1 Nanoscale polymer vehicles based on Hyaluronic Acid (HA) and poly-Cyclodextrin (CD) are very promising transport systems for delivering chemotherapeutic and biological drugs due to their aqueous solubility, low toxicity or immunity and supramolecular self-assembly ability after chemical modification. Here we describe the supramolecular nanoassemblies obtained by HA functionalized with ?-CD2 and by cationic-cyclodextrin polymer. Their drug binding abilities have been investigated by complementary spectroscopic techniques including UV-Vis, ?-potential and DLS, using acyclovir and diclofenac as model drugs.
SUPRAMOLECULAR NANOASSEMBLIES BASED ON HYALURONIC ACID AND POLYMERIC CYCLODEXTRINS AS THERAPEUTIC PLATFORMS
Annalaura Cordaro;Roberto Zagami;Antonino Mazzaglia;
2019
Abstract
The development of functional supramolecular polymers, that readily self-assemble in aqueous media into structurally stable nanoconstructs with high drug loading capacity and controlled drug release ability under different environmental conditions, has recently attracted considerable attention as an efficient strategy to improve the efficiency of current drug delivery systems.1 Nanoscale polymer vehicles based on Hyaluronic Acid (HA) and poly-Cyclodextrin (CD) are very promising transport systems for delivering chemotherapeutic and biological drugs due to their aqueous solubility, low toxicity or immunity and supramolecular self-assembly ability after chemical modification. Here we describe the supramolecular nanoassemblies obtained by HA functionalized with ?-CD2 and by cationic-cyclodextrin polymer. Their drug binding abilities have been investigated by complementary spectroscopic techniques including UV-Vis, ?-potential and DLS, using acyclovir and diclofenac as model drugs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
