Systemic Wound Healing Associated with local subCutaneous Mechanical Stimulation (vol 6, 39043, 2017)

Degeneration is a hallmark of autoimmune diseases, whose incidence grows worldwide. Currenttherapies attempt to control the immune response to limit degeneration, commonly promotingimmunodepression. Differently, mechanical stimulation is known to trigger healing (regeneration) andit has recently been proposed locally for its therapeutic potential on severely injured areas. As the earlystages of healing consist of altered intra- and inter-cellular fluxes of soluble molecules, we explored thepotential of this early signal to spread, over time, beyond the stimulation district and become systemic,to impact on distributed or otherwise unreachable injured areas. We report in a model of arthritis inrats how stimulations delivered in the subcutaneous dorsal tissue result, over time, in the control andhealing of the degeneration of the paws' joints, concomitantly with the systemic activation of woundhealing phenomena in blood and in correlation with a more eubiotic microbiome in the gut intestinaldistrict.