Nowadays, phototherepeutic systems based on cyclodextrin (CD) at nanoscale level are an intriguing class of constructs that possess great chances to be proposed in the treatments of different diseases [1-2]. Here we discuss on our recent advances on nanophototherapeutics designed for both passive and active targeting, based on non ionic amphiphilic CD (aCD) and loaded with photosensitisers [3] (i.e. BODIPY and pophyrinoids). In particular, the selected examples will elucidate as the choice of the molecular components and their supramolecular arrangement affects the photophysical and stability of actively-targeted nanophototherapeutics in biologically relevant media, their cellular biofate and the phototoxicity in tumoral cell lines. These results can open routes for in vivo translational studies on novel nano(photo)drugs and nanotheranostics based on CD [4].
BIO-SOFT CYCLODEXTRINS NANOPHOTOTHERAPEUTICS: RECENT ADVANCES AND PERSPECTIVES
Roberto Zagami;Antonino Mazzaglia
2019
Abstract
Nowadays, phototherepeutic systems based on cyclodextrin (CD) at nanoscale level are an intriguing class of constructs that possess great chances to be proposed in the treatments of different diseases [1-2]. Here we discuss on our recent advances on nanophototherapeutics designed for both passive and active targeting, based on non ionic amphiphilic CD (aCD) and loaded with photosensitisers [3] (i.e. BODIPY and pophyrinoids). In particular, the selected examples will elucidate as the choice of the molecular components and their supramolecular arrangement affects the photophysical and stability of actively-targeted nanophototherapeutics in biologically relevant media, their cellular biofate and the phototoxicity in tumoral cell lines. These results can open routes for in vivo translational studies on novel nano(photo)drugs and nanotheranostics based on CD [4].I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
