The present chapter discusses the development of biocomposites as scaffolds for tissue regeneration, particularly in reconstructive procedures for bone and multifunctional anatomical regions such as the joints and the periodontium. After a brief introduction of the solutions and technologies currently adopted in the repair and regeneration of hard connective tissues, the chapter illustrates the most recent innovative solutions, following three different approaches: - the exploitation of bio-inspired assembling/mineralisation processes, able to yield hybrid porous materials for bone regeneration and in the form of graded multifunctional scaffolds mimicking osteochondral and periodontal regions; - the use of natural structures (such as wood, plants, exoskeletons, silk, cuttlefish) as 3D models for the development of biomimetic, hierarchically organised scaffolds for long segmental bones, to be obtained by biomorphic transformations; and - the use of new biocompatible, resorbable, and magnetic biomaterials as potential multifunctional platform in bone regeneration.

Developing biocomposites as scaffolds in regenerative medicine

Sprio S;Iafisco M;Ruffini A;Panseri S;Montesi M;Adamiano A;Tampieri A
2017

Abstract

The present chapter discusses the development of biocomposites as scaffolds for tissue regeneration, particularly in reconstructive procedures for bone and multifunctional anatomical regions such as the joints and the periodontium. After a brief introduction of the solutions and technologies currently adopted in the repair and regeneration of hard connective tissues, the chapter illustrates the most recent innovative solutions, following three different approaches: - the exploitation of bio-inspired assembling/mineralisation processes, able to yield hybrid porous materials for bone regeneration and in the form of graded multifunctional scaffolds mimicking osteochondral and periodontal regions; - the use of natural structures (such as wood, plants, exoskeletons, silk, cuttlefish) as 3D models for the development of biomimetic, hierarchically organised scaffolds for long segmental bones, to be obtained by biomorphic transformations; and - the use of new biocompatible, resorbable, and magnetic biomaterials as potential multifunctional platform in bone regeneration.
2017
Istituto di Scienza, Tecnologia e Sostenibilità per lo Sviluppo dei Materiali Ceramici - ISSMC (ex ISTEC)
978-0-08-100752-5
Hard tissue regeneration
Biomimesis
Biomineralisation
Biomorphic transformation
Bio-hybrid composites
Hierarchically organised scaffold
Natural template
Osteochondral scaffold
Dental scaffolds
Limb regeneration
Magnetic activation
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/389013
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 2
social impact