Gallo et al. explore how cells repair ssDNA that arises from exogenous and endogenous DNA replication stress. They reveal that recruitment of error-prone polymerases to stressed replication forks results in mutagenic repair of ssDNA. These findings point to an expanded role of error-prone polymerases in replicating the eukaryotic genome.
Rad5 Recruits Error-Prone DNA Polymerases for Mutagenic Repair of ssDNA Gaps on Undamaged Templates
Branzei D;
2019
Abstract
Gallo et al. explore how cells repair ssDNA that arises from exogenous and endogenous DNA replication stress. They reveal that recruitment of error-prone polymerases to stressed replication forks results in mutagenic repair of ssDNA. These findings point to an expanded role of error-prone polymerases in replicating the eukaryotic genome.File in questo prodotto:
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