A small collection of C2-symmetry hydroxylated biphenyls derivatives featured with a ?,?-unsaturated ketone as lead structure21 was prepared and the capability of such compounds to act as antiproliferative agents against four human malignant melanoma cell lines22 was assayed. The prodrug approach was applied in order to improve delivery of compounds into the cell by modulation of the phenolic23 OH protective group. The hydroxylated biphenyl structure bearing an ?,?-unsaturated ketone and a phenolic-O-prenylated chain would24 facilitated the delivery of the molecule and interac
Synthesis of Hydroxylated Biphenyls Derivatives Bearing an Alpha, Beta-Unsaturated Ketone as Lead Structure for the Development of New Drug Candidates Against Malignant Melanoma
Maria Antonietta Dettori;Davide Fabbri
;Marina Pisano;Carla Rozzo;Giovanna Delogu
2021
Abstract
A small collection of C2-symmetry hydroxylated biphenyls derivatives featured with a ?,?-unsaturated ketone as lead structure21 was prepared and the capability of such compounds to act as antiproliferative agents against four human malignant melanoma cell lines22 was assayed. The prodrug approach was applied in order to improve delivery of compounds into the cell by modulation of the phenolic23 OH protective group. The hydroxylated biphenyl structure bearing an ?,?-unsaturated ketone and a phenolic-O-prenylated chain would24 facilitated the delivery of the molecule and interacFile in questo prodotto:
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Descrizione: Synthesis of Hydroxylated Biphenyl Derivatives Bearing an α,β-Unsaturated Ketone as a Lead Structure for the Development of Drug Candidates against Malignant Melanoma
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ChemMedChem - 2020 - Dettori.pdf
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Descrizione: Synthesis of Hydroxylated Biphenyl Derivatives Bearing an α,β-Unsaturated Ketone as a Lead Structure for the Development of Drug Candidates against Malignant Melanoma
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