Blood Pressure Variability, Mortality, and Cardiovascular Outcomes in CKD Patients

Design, setting, participants, & measurements In a cohort of 402 patients with CKD, we assessed associations of short-and long-term systolic BP variability with a composite end point of death or cardiovascular event. Variabilitywas defined as the standard deviation of observed BPmeasurements. Wefurther tested the prognostic value of these parameters for risk discrimination and reclassification.

Background and objectives Short-termBP variability (derived from24-hourambulatory BPmonitoring) and longterm BP variability (from clinic visit to clinic visit) are directly related to risk for cardiovascular events, but these relationshipshave been scarcelyinvestigatedinpatientswithCKD, andtheirprognosticvalue in thispopulationis unknown.