In this work we investigated how serum protein adsorption on NP surfaces infl uences the cellular uptake of NPs. We fi nd that surface hydrophobicity is a critical factor for controlling serum albumin binding, which in turn decreases the cellular uptake of AuNPs.

The Interplay of Monolayer Structure and Serum Protein Interactions on the Cellular Uptake of Gold Nanoparticles

Posati Tamara;
2012

Abstract

In this work we investigated how serum protein adsorption on NP surfaces infl uences the cellular uptake of NPs. We fi nd that surface hydrophobicity is a critical factor for controlling serum albumin binding, which in turn decreases the cellular uptake of AuNPs.
2012
Inglese
8
17
2659
2663
5
Sì, ma tipo non specificato
gold nanoparticles
cellular uptake
hydrophobicity
protein absorption
structure-protein interactions
1
info:eu-repo/semantics/article
262
Zhu, ZhengJiang; Posati, Tamara; Moyano, Daniel F.; Tang, Rui; Yan, Bo; Vachet, Richard W.; Rotello, Vincent M.
01 Contributo su Rivista::01.01 Articolo in rivista
none
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/394017
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 73
social impact