The solid-phase synthesis of Gly-?[CH(CF3)NH]-peptides is presented. In order to achieve this goal, the synthesis of Gly-?[CH(CF3)NH]-dipeptides having the C-Terminus unprotected, the N-Terminus protected as Fmoc-or Teoc-, and possibly side chain functionalities protected with acid-labile protecting groups has been developed. A selected small library of six peptidomimetics, encompassing analogues of biological relevant peptides, have been obtained in high purity.
Solid-Phase Synthesis of Gly-?[CH(CF3)NH]-Peptides
Lo Presti E;Bergamaschi G;Sani M;Volonterio A
2021
Abstract
The solid-phase synthesis of Gly-?[CH(CF3)NH]-peptides is presented. In order to achieve this goal, the synthesis of Gly-?[CH(CF3)NH]-dipeptides having the C-Terminus unprotected, the N-Terminus protected as Fmoc-or Teoc-, and possibly side chain functionalities protected with acid-labile protecting groups has been developed. A selected small library of six peptidomimetics, encompassing analogues of biological relevant peptides, have been obtained in high purity.File in questo prodotto:
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