Cyclodextrins (CD) are cyclic oligosaccharides consisting alfa-D-glucopyranosyl units linked through1,4-linkages, which are obtained from enzymatic degradation of starch. The co-existence ofhydrophilic and hydrophobic regions in the same structure makes these macrocycles extremelyversatile as complexing host with application in food, cosmetics, environmental, agriculture, textile,pharmaceutical and chemical industries. Due to their inherent chirality, CDs have been also successfully used as chiral selectors in enantioseparation science, in particular for capillary electrophoresis (CE) enantioseparations. In the last decades, multidisciplinary approaches based on CE, NMR spectroscopy, X-ray crystallography, microcalorimetry, and molecular modeling have shed light on some aspects of recognition mechanisms underlying enantiodiscrimination. With the ever growing improvement of computer facilities, hardware and software, computational techniques have become a useful tool to model at molecular level the dynamics of diastereomeric associate formation to sample low-energy conformations, the binding energies between the enantiomer and the CD, and to profile noncovalent interactions contributing to the stability of CD/enantiomer association. On this basis, the aim of this review is to provide the reader with a critical overview on the applications of CDs in CE. In particular, the contemporary theory of the electrophoretic technique and the main structural features of CDs are described, with a specific focus on techniques, methods and approaches to model CE enantioseparations promoted by native and substituted CDs. A systematic compilation of all published literature has not been attempted.
Native and substituted cyclodextrins as chiral selectors for capillary electrophoresis enantioseparations: structures, features, application, and molecular modeling
Paola Peluso
;
2021
Abstract
Cyclodextrins (CD) are cyclic oligosaccharides consisting alfa-D-glucopyranosyl units linked through1,4-linkages, which are obtained from enzymatic degradation of starch. The co-existence ofhydrophilic and hydrophobic regions in the same structure makes these macrocycles extremelyversatile as complexing host with application in food, cosmetics, environmental, agriculture, textile,pharmaceutical and chemical industries. Due to their inherent chirality, CDs have been also successfully used as chiral selectors in enantioseparation science, in particular for capillary electrophoresis (CE) enantioseparations. In the last decades, multidisciplinary approaches based on CE, NMR spectroscopy, X-ray crystallography, microcalorimetry, and molecular modeling have shed light on some aspects of recognition mechanisms underlying enantiodiscrimination. With the ever growing improvement of computer facilities, hardware and software, computational techniques have become a useful tool to model at molecular level the dynamics of diastereomeric associate formation to sample low-energy conformations, the binding energies between the enantiomer and the CD, and to profile noncovalent interactions contributing to the stability of CD/enantiomer association. On this basis, the aim of this review is to provide the reader with a critical overview on the applications of CDs in CE. In particular, the contemporary theory of the electrophoretic technique and the main structural features of CDs are described, with a specific focus on techniques, methods and approaches to model CE enantioseparations promoted by native and substituted CDs. A systematic compilation of all published literature has not been attempted.File | Dimensione | Formato | |
---|---|---|---|
2021_Electrophoresis.pdf
solo utenti autorizzati
Descrizione: Native and substituted cyclodextrins as chiral selectors for capillary electrophoresis enantioseparations: Structures, features, application, and molecular modeling
Tipologia:
Versione Editoriale (PDF)
Licenza:
NON PUBBLICO - Accesso privato/ristretto
Dimensione
3.15 MB
Formato
Adobe PDF
|
3.15 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
2021_Electrophoresis.pdf
Open Access dal 23/05/2022
Descrizione: Native and substituted cyclodextrins as chiral selectors for capillary electrophoresis enantioseparations: Structures, features, application, and molecular modeling
Tipologia:
Documento in Post-print
Licenza:
Creative commons
Dimensione
1.04 MB
Formato
Adobe PDF
|
1.04 MB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.