The study of single nucleotide polymorphisms (SNPs) in the miRNA regulatory network could help shed light on the causality of associations as well as validate the value of cardiovascular miRNAs. SNPs in miRNA biogenesis or miRNA targetome genes may affect miRNA expression and circulating levels or the fidelity of the miRNA-mRNA interaction, influencing susceptibility to atherosclerotic vascular disease.
There is growing interest in the potential of circulating microRNAs (miRNAs), a class of small and noncoding RNA molecules, as diagnostic and/or prognostic biomarkers in coronary artery disease (CAD). Despite this promising role, there are still widespread inconsistencies among studies, and important obstacles must be overcome before miRNAs can enter clinical practice.
Genetic polymorphisms offer insight into the causal role of microRNA in coronary artery disease
Borghini Andrea;
2018
Abstract
There is growing interest in the potential of circulating microRNAs (miRNAs), a class of small and noncoding RNA molecules, as diagnostic and/or prognostic biomarkers in coronary artery disease (CAD). Despite this promising role, there are still widespread inconsistencies among studies, and important obstacles must be overcome before miRNAs can enter clinical practice.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
