Alpha-Tricalcium Phosphate Based Brushite Cement For Osteoplastics - Some Physicochemical And Biological Characteristics In Vitro

Calcium phosphate cements (CPCs) are advanced materials to fill bone tissue defects due to the complex of benefits [1, 2]. CPCs have a simple protocol of preparation and application, set under physiological conditions and exhibit osteoconductive properties. The bioresorption rate of brushite cements (BCs) is close to growth rate of bone de novo. The main lack of BCs is poor mechanical properties and acidosis of surrounding tissues during setting and hardening. Carbonated hydroxyapatite ceramics granules can be used to enhance mechanical characteristics of BCs and to stabilize pH values close to neutral of the BCs surrounding media, simultaneously. Moreover, to prevent deformations of BCs scaffolds, porous polylactide (PL) framework with Kelvin structure can be applied as reinforcement. Current investigation is focused on in vitro study of the BCs with the addition of carbonated hydroxyapatite (CHA) granules and reinforced by the porous polylactide frame.