Herkenne et al. report that the mitochondria-shaping protein OPA1 is an essential component of both developmental and tumor angiogenesis. They discover a first-in-class small molecule that is specific to OPA1 and can pharmacologically target endothelial OPA1 to curtail tumor growth.
Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1
Di Benedetto G;
2020
Abstract
Herkenne et al. report that the mitochondria-shaping protein OPA1 is an essential component of both developmental and tumor angiogenesis. They discover a first-in-class small molecule that is specific to OPA1 and can pharmacologically target endothelial OPA1 to curtail tumor growth.File in questo prodotto:
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