The surname of the second author was incorrect in the published version of the paper; the corrected version is shown above. The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers. Reactions of cytotoxic platinum drugs with proteins are attracting growing attention for their relevant biological implications. We report here on the reactions of two cis-diphosphane platinum(II) dichlorides (namely cis-bis(trimethylphosphane) platinum(II) dichloride and cis-bis(triethylphosphane) platinum(II) dichloride) with horse heart cytochrome c (cyt c) monitored through advanced ESI MS methods coupled to enzymatic digestion. A remarkable selectivity in terms of adduct stoichiometry is highlighted and the specific metal binding sites are localised on the protein surface.
Correction: Reactions of metallodrugs with proteins: Selective binding of phosphane-based platinum(ii) dichlorides to horse heart cytochrome: C probed by ESI MS coupled to enzymatic cleavage (Metallomics (2011) 3 (987-990) DOI: 10.1039/c1mt00069a)
Michelucci E;
2018
Abstract
The surname of the second author was incorrect in the published version of the paper; the corrected version is shown above. The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers. Reactions of cytotoxic platinum drugs with proteins are attracting growing attention for their relevant biological implications. We report here on the reactions of two cis-diphosphane platinum(II) dichlorides (namely cis-bis(trimethylphosphane) platinum(II) dichloride and cis-bis(triethylphosphane) platinum(II) dichloride) with horse heart cytochrome c (cyt c) monitored through advanced ESI MS methods coupled to enzymatic digestion. A remarkable selectivity in terms of adduct stoichiometry is highlighted and the specific metal binding sites are localised on the protein surface.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
