Herein we report the synthesis of cellulose nanocrystals covalently bound to a model chemother- apeutic drug (DOXO) via a novel spacer arm, which acts both as linker and as selective releasing agent. The carbamate linkage present in the linker, shows stability in aqueous environments for a wide range of condi- tions and can only be hydrolyzed in the presence of cells, freeing the active drug, with unmodified chemotherapeutic properties.
Biocompatible Pectin-based Hybrid Hydrogels for Tissue Engineering Applications
Chiariello M;
2021
Abstract
Herein we report the synthesis of cellulose nanocrystals covalently bound to a model chemother- apeutic drug (DOXO) via a novel spacer arm, which acts both as linker and as selective releasing agent. The carbamate linkage present in the linker, shows stability in aqueous environments for a wide range of condi- tions and can only be hydrolyzed in the presence of cells, freeing the active drug, with unmodified chemotherapeutic properties.File in questo prodotto:
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