ADViSELipidomics: a workflow for analyzing lipidomics data

Summary: ADViSELipidomics is a novel Shiny app for preprocessing, analyzing and visualizing lipidomics data. Ithandles the outputs from LipidSearch and LIQUID for lipid identification and quantification and the data fromthe Metabolomics Workbench. ADViSELipidomics extracts information by parsing lipid species (using LIPID MAPSclassification) and, together with information available on the samples, performs several exploratory and statisticalanalyses. When the experiment includes internal lipid standards, ADViSELipidomics can normalize the data matrix,providing normalized concentration values per lipids and samples. Moreover, it identifies differentially abundantlipids in simple and complex experimental designs, dealing with batch effect correction. Finally, ADViSELipidomicshas a user-friendly graphical user interface and supports an extensive series of interactive graphics.