Based on ESI-MS measurements, we show here that some representative cytotoxic gold(iii) compounds produce stable adducts upon reaction with the copper chaperone Atox-1; notably, such adducts contain gold in the oxidation state +1. These findings are of interest to understand the intracellular metabolism of medicinal gold species and to develop new potent inhibitors of the copper trafficking system.
Medicinal gold compounds form tight adducts with the copper chaperone Atox-1: Biological and pharmacological implications
Michelucci E;
2012
Abstract
Based on ESI-MS measurements, we show here that some representative cytotoxic gold(iii) compounds produce stable adducts upon reaction with the copper chaperone Atox-1; notably, such adducts contain gold in the oxidation state +1. These findings are of interest to understand the intracellular metabolism of medicinal gold species and to develop new potent inhibitors of the copper trafficking system.File in questo prodotto:
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