The synthesis and characterization of a small series of cyclic triimidazole derivatives functionalized with methylated pyridine or guanidine moieties is reported. These compounds were tested for their ability to bind to G-quadruplexes from both telomeric and oncogene promoter sequences. Some of them exhibited high affinity and effective G-quadruplex-stabilizing properties. Overall, these compounds may represent useful leads for developing more potent and selective analogues.
Cyclic Triimidazoles as Stabilizers for Gene Promoter and Human Telomeric DNA G-Quadruplexes
D. Malpicci;E. Lucenti;E. Cariati;
2022
Abstract
The synthesis and characterization of a small series of cyclic triimidazole derivatives functionalized with methylated pyridine or guanidine moieties is reported. These compounds were tested for their ability to bind to G-quadruplexes from both telomeric and oncogene promoter sequences. Some of them exhibited high affinity and effective G-quadruplex-stabilizing properties. Overall, these compounds may represent useful leads for developing more potent and selective analogues.File in questo prodotto:
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Eur J Org Chem - 2022 - Malpicci - Cyclic Triimidazoles as Stabilizers for Gene Promoter and Human Telomeric DNA.pdf
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