A proper use of agrochemicals provides crop security and abundant production. Nevertheless, without an appropriate formulation even the most effective compound is worth nothing. In the search of sustainable matrices, we have assayed the ability of ?-cyclodextrin (?-CD) to activate strong interactions with compounds with potential insecticidal and fungicidal activities and useful in sustainable agriculture. We experimented the inclusion complex properties of ?-CD with natural and edible phenols that manifest repellent activity against Drosophila suzukii, a pest that affects small fruits. These inclusion complexes showed promising results in term of oviposition-deterrent activity.[1] Inclusion of such phenols in ?-CD enhances the efficacy of these compounds avoiding their evaporation and inactivation by contact with soil, permitting a controlled release of the guest. Several natural phenols were tested in vitro and in the field against Fusarium culmorum (FC) and F. graminearum (FG), fungi that cause diseases on cereals and produces mycotoxins that cause toxicosis in humans. In an attempt to improve bioavailability of the phenols with fungicidal activity, aqueous solution of ?-CD with the compounds were prepared.[2a,b] The procedure was carried out in a way to exclude any stable inclusion of the compound into the ?-CD cavity and to activate strong interactions with the phenols allowing their solubilisation in water. Complete fungicide and strong mycotoxin inhibitory activities were observed for some of the phenols treated with ?-CD solutions. Cyclodextrins interact with molecules and biological systems at different levels and an enhancement of agrochemical effectiveness of the couple ?-CD/molecule even at level of physical mixture cannot be ruled out. This was verified by a simple experimental system with mealworm larvae (Tenebrio molitor) as the pest, diflubenzuron (active ingredient of a commercial insecticide), and ?-CD (adjuvant).[3] The physical mixture with ?-CD increased the pest mortality by enhancing the effectiveness of diflubenzuron.
Beta-cd as multipurpose matrix to improve bioavailability of valuable phenols in sustainable agriculture strategies
D Fabbri;MA Dettori;P Carta;G Delogu
2022
Abstract
A proper use of agrochemicals provides crop security and abundant production. Nevertheless, without an appropriate formulation even the most effective compound is worth nothing. In the search of sustainable matrices, we have assayed the ability of ?-cyclodextrin (?-CD) to activate strong interactions with compounds with potential insecticidal and fungicidal activities and useful in sustainable agriculture. We experimented the inclusion complex properties of ?-CD with natural and edible phenols that manifest repellent activity against Drosophila suzukii, a pest that affects small fruits. These inclusion complexes showed promising results in term of oviposition-deterrent activity.[1] Inclusion of such phenols in ?-CD enhances the efficacy of these compounds avoiding their evaporation and inactivation by contact with soil, permitting a controlled release of the guest. Several natural phenols were tested in vitro and in the field against Fusarium culmorum (FC) and F. graminearum (FG), fungi that cause diseases on cereals and produces mycotoxins that cause toxicosis in humans. In an attempt to improve bioavailability of the phenols with fungicidal activity, aqueous solution of ?-CD with the compounds were prepared.[2a,b] The procedure was carried out in a way to exclude any stable inclusion of the compound into the ?-CD cavity and to activate strong interactions with the phenols allowing their solubilisation in water. Complete fungicide and strong mycotoxin inhibitory activities were observed for some of the phenols treated with ?-CD solutions. Cyclodextrins interact with molecules and biological systems at different levels and an enhancement of agrochemical effectiveness of the couple ?-CD/molecule even at level of physical mixture cannot be ruled out. This was verified by a simple experimental system with mealworm larvae (Tenebrio molitor) as the pest, diflubenzuron (active ingredient of a commercial insecticide), and ?-CD (adjuvant).[3] The physical mixture with ?-CD increased the pest mortality by enhancing the effectiveness of diflubenzuron.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
