In this study, for the first time, 5-Fluorouracil was entrapped in blend nanosystems made up of sericin and zein by means of an easy and economic approach. The nanoblends showed mean sizes of 100-150 nm, a monodispersed population, high stability in serum, 6 months storage stability and the possibility to be freeze-dried. In addition, the colloidal blend systems showed a greater ability to hold the bioactive compound as compared to the zein nanosystems, and promoted a gradual release of the drug. The nanoblend preserved the pharmacological activity of 5-Fluouracil against cancer cells, suggesting the potential application of this novel formulation in antitumor therapy.

Easy preparation, characterization and cytotoxic investigation of 5-Fluorouracil-loaded zein/sericin nanoblends

Salvatici MC;
2022

Abstract

In this study, for the first time, 5-Fluorouracil was entrapped in blend nanosystems made up of sericin and zein by means of an easy and economic approach. The nanoblends showed mean sizes of 100-150 nm, a monodispersed population, high stability in serum, 6 months storage stability and the possibility to be freeze-dried. In addition, the colloidal blend systems showed a greater ability to hold the bioactive compound as compared to the zein nanosystems, and promoted a gradual release of the drug. The nanoblend preserved the pharmacological activity of 5-Fluouracil against cancer cells, suggesting the potential application of this novel formulation in antitumor therapy.
2022
Istituto di Chimica dei Composti OrganoMetallici - ICCOM -
5-Fluorouracil; Blend nanoparticles; Sericin; Zein
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Descrizione: Easy preparation, characterization and cytotoxic investigation of 5-Fluorouracil-loaded zein/sericin nanoblends
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/417556
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