In this study, for the first time, 5-Fluorouracil was entrapped in blend nanosystems made up of sericin and zein by means of an easy and economic approach. The nanoblends showed mean sizes of 100-150 nm, a monodispersed population, high stability in serum, 6 months storage stability and the possibility to be freeze-dried. In addition, the colloidal blend systems showed a greater ability to hold the bioactive compound as compared to the zein nanosystems, and promoted a gradual release of the drug. The nanoblend preserved the pharmacological activity of 5-Fluouracil against cancer cells, suggesting the potential application of this novel formulation in antitumor therapy.

Easy preparation, characterization and cytotoxic investigation of 5-Fluorouracil-loaded zein/sericin nanoblends

Salvatici MC;
2022

Abstract

In this study, for the first time, 5-Fluorouracil was entrapped in blend nanosystems made up of sericin and zein by means of an easy and economic approach. The nanoblends showed mean sizes of 100-150 nm, a monodispersed population, high stability in serum, 6 months storage stability and the possibility to be freeze-dried. In addition, the colloidal blend systems showed a greater ability to hold the bioactive compound as compared to the zein nanosystems, and promoted a gradual release of the drug. The nanoblend preserved the pharmacological activity of 5-Fluouracil against cancer cells, suggesting the potential application of this novel formulation in antitumor therapy.
2022
Istituto di Chimica dei Composti OrganoMetallici - ICCOM -
5-Fluorouracil; Blend nanoparticles; Sericin; Zein
File in questo prodotto:
File Dimensione Formato  
prod_471380-doc_191426.pdf

solo utenti autorizzati

Descrizione: Easy preparation, characterization and cytotoxic investigation of 5-Fluorouracil-loaded zein/sericin nanoblends
Tipologia: Versione Editoriale (PDF)
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 4.17 MB
Formato Adobe PDF
4.17 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/417556
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 9
  • ???jsp.display-item.citation.isi??? ND
social impact