This study aims to investigate the effects of 1950 MHz, LTE signal radiofrequency exposure, administered alone and in combination with a wellknown genotoxic agent, the mytomycin-C (MMC). In particular, V79 cell cultures were exposed/sham exposed in a waveguide-based system for 3h and 20 h at 0.3 W/kg and 1.25 W/kg specific absorption rate (SAR) to evaluate the chromosomal damage in the micronucleus (MN) assay. We did not reveal effects of RF exposure alone, instead a reduction of the MMC-induced damage was detected when cells were pre-exposed for 20 h to 1.25 W/kg SAR. Moreover, we did not evidence alteration of the intracellular levels of HSF1 and PARP1 in western blot preliminary experiments.
The effect of combined exposure to radiofrequency LTE signal and mitomycin-C in Chinese Hamster Lung Fibroblast cells
Anna Sannino;Stefania Romeo;Maria Rosaria Scarfi;Loredana Poeta;Mario Alonzo;Olga Zeni
2022
Abstract
This study aims to investigate the effects of 1950 MHz, LTE signal radiofrequency exposure, administered alone and in combination with a wellknown genotoxic agent, the mytomycin-C (MMC). In particular, V79 cell cultures were exposed/sham exposed in a waveguide-based system for 3h and 20 h at 0.3 W/kg and 1.25 W/kg specific absorption rate (SAR) to evaluate the chromosomal damage in the micronucleus (MN) assay. We did not reveal effects of RF exposure alone, instead a reduction of the MMC-induced damage was detected when cells were pre-exposed for 20 h to 1.25 W/kg SAR. Moreover, we did not evidence alteration of the intracellular levels of HSF1 and PARP1 in western blot preliminary experiments.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
