Background: Numerous currently incurable human diseases have been causally linked to mutations in connexin (Cx) genes. In several instances, pathological mutations generate abnormally active Cx hemichannels, referred to also as "leaky" hemichannels. The goal of this study was to assay the in vivo efficacy of a potent antagonist antibody targeting Cx hemichannels.
A potent antagonist antibody targeting connexin hemichannels alleviates Clouston syndrome symptoms in mutant mice
Ziraldo Gaia;Peres Chiara;Nardin Chiara;Salvatore Anna Maria;Chiani Francesco;Scavizzi Ferdinando;Raspa Marcello;Mammano Fabio
2020
Abstract
Background: Numerous currently incurable human diseases have been causally linked to mutations in connexin (Cx) genes. In several instances, pathological mutations generate abnormally active Cx hemichannels, referred to also as "leaky" hemichannels. The goal of this study was to assay the in vivo efficacy of a potent antagonist antibody targeting Cx hemichannels.File in questo prodotto:
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