l. The biosynthetic origin of the verrucosins, ichthyotoxic diacylglycerols of the nudibranch mollusc Doris verrucosa, has been investigated by administration of [2J4C]mevalonic acid and [U-14C] -glycerol. The poor incorporation results do not clearly establish the existence of a de novo biosynthesis. 2. The comparison of the secondary metabolites in D. verrucosa specimens collected in different habitats, as well as of the secondary metabolites of its principal prey, the sponge Hymeniacidon sanguinea, suggest that verrucosins are biosynthesized de novo by the mollusc. 3. A good incorporation of [2-14C]mevalonic acid into the sterols established that the mevalonate pathway is operative in D. verrucosa.
BIOSYNTHETIC ORIGIN AND ANATOMICAL DISTRIBUTION OF THE MAIN SECONDARY METABOLITES IN THE NUDIBRANCH MOLLUSK DORIS-VERRUCOSA
CIMINO G;
1990
Abstract
l. The biosynthetic origin of the verrucosins, ichthyotoxic diacylglycerols of the nudibranch mollusc Doris verrucosa, has been investigated by administration of [2J4C]mevalonic acid and [U-14C] -glycerol. The poor incorporation results do not clearly establish the existence of a de novo biosynthesis. 2. The comparison of the secondary metabolites in D. verrucosa specimens collected in different habitats, as well as of the secondary metabolites of its principal prey, the sponge Hymeniacidon sanguinea, suggest that verrucosins are biosynthesized de novo by the mollusc. 3. A good incorporation of [2-14C]mevalonic acid into the sterols established that the mevalonate pathway is operative in D. verrucosa.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
