Methods: The study lasted 28 days and included healthy animals administered with GS (daily dose of 200 mg/kg), untreated arthritic rats and arthritic rats treated with: GS, methotrexate in single treatment or in combination with GS. Arthritic score and changes in body weigh were measured during the treatment while inflammatory markers (monocyte chemotactic protein-1, IL-17 and inducible NO-synthase mRNA) and biochemical parameters (gamma-glutamyltransferase and heme oxygenase-1) at the end of the treatment.
Background: Green tea catechins are widely employed as dietary supplements to restore the oxidative state in adjuvant-induced arthritic rats, a model for human rheumatoid arthritis. Methotrexate is the first line anti rheumatic drug. The present study aimed to investigate if a decaffeinated extract (GreenSelect (R), GS) of tea polyphenols can ameliorate methotrexate treatment in rat adjuvant arthritis.
Modulation of methotrexate efficacy by green tea polyphenols in rat adjuvant arthritis
Tedesco Idolo;Russo Gian Luigi
2020
Abstract
Background: Green tea catechins are widely employed as dietary supplements to restore the oxidative state in adjuvant-induced arthritic rats, a model for human rheumatoid arthritis. Methotrexate is the first line anti rheumatic drug. The present study aimed to investigate if a decaffeinated extract (GreenSelect (R), GS) of tea polyphenols can ameliorate methotrexate treatment in rat adjuvant arthritis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
