In this article Minchiotti, Patriarca, and colleagues show that gastruloid formation provides an additional test of the developmental fidelity of stem cells. This study reveals that LIF exerts a dominant effect over exogenous FGF/ACTIVIN to provide gastruloid development competence, and suggests that a certain degree of phenotypic heterogeneity in the stem cell population is essential to generate functional cell aggregates.
Gastruloid Development Competence Discriminates Different States of Pluripotency
Cermola Federica;D'Aniello Cristina;Tatè Rosarita;De Cesare Dario;Minchiotti Gabriella
;Patriarca Eduardo Jorge
2021
Abstract
In this article Minchiotti, Patriarca, and colleagues show that gastruloid formation provides an additional test of the developmental fidelity of stem cells. This study reveals that LIF exerts a dominant effect over exogenous FGF/ACTIVIN to provide gastruloid development competence, and suggests that a certain degree of phenotypic heterogeneity in the stem cell population is essential to generate functional cell aggregates.File in questo prodotto:
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Cermola et al. _SCR 2021.pdf
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