Texture analysis to assess structural modifications induced by radiotherapy

Texture analysis is an emerging tool employed in Radiotherapy (RT) to improve tumor characterization for planning and to evaluate treatment effects. In the treatment of Head and Neck Cancer, parotid glands can receive high dose that may compromise gland functionality and structure. Texture analysis was here applied on CT images of Head and Neck to evaluate changes in parotid gland structure during RT. CT images at the beginning, at the intermediate stage and at the end of RT were considered and in each time point different features (i.e. mean intensity, variance, entropy, homogeneity, local entropy, fractal dimension and volume) were extracted within parotid volume. A general decrease in tissue complexity and heterogeneity was found, with different time trend for textural features. This is explainable by different biological mechanisms associated to the variation of each index. Volume and mean intensity variation are also correlated with some pre-treatment dosimetric parameters, indicating a relationship between the dose plan and the structural variation estimated after RT.