Materials and methods: Within the Italian GENOCOR cohort, we studied a cohort of 557 patients (502 males, 57 +/- 9 years) with angiographically documented CAD. A total of 443 healthy controls (262 males, 56 +/- 12 years) was also enrolled. Genotyping was determined by using a TaqMan (R) SNP genotyping assay. Analysis of miR-132 and miR-140-3p was assessed in a subset of 70 CAD patients by using qRT-PCR.
Introduction: Single-nucleotide polymorphisms (SNPs) in microRNA (miRNA) machinery genes may affect the regulatory capacity of miRNAs by impacting their biogenesis. The aim of the study was to analyze the association between SNPs in two key genes (DICER rs1057035T > C and XPO5 rs11077A > C) and coronary artery disease (CAD) risk as well as to examine their effects on circulating levels of vascular miRNAs.
Influence of genetic polymorphisms in DICER and XPO5 genes on the risk of coronary artery disease and circulating levels of vascular miRNAs
Borghini Andrea;Mercuri Antonella;Vecoli Cecilia;Carpeggiani Clara;
2019
Abstract
Introduction: Single-nucleotide polymorphisms (SNPs) in microRNA (miRNA) machinery genes may affect the regulatory capacity of miRNAs by impacting their biogenesis. The aim of the study was to analyze the association between SNPs in two key genes (DICER rs1057035T > C and XPO5 rs11077A > C) and coronary artery disease (CAD) risk as well as to examine their effects on circulating levels of vascular miRNAs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
