Methods: Within the Italian GENOCOR (Genetic Mapping for Assessment of Cardiovascular Risk) cohort, we studied 515 patients (450 males, 65 +/- 8 years) with known or suspected stable CAD. mtDNA(4977) deletion and mtDNA-CN were assessed in peripheral blood using qRT-PCR.
Background and aims: Mitochondrial DNA copy number (mtDNA-CN) depletion has been recently associated with an increased cardiovascular risk. However, the integrity of mtDNA is another key aspect of the energy metabolism and mitochondrial function. We investigated the prognostic role of peripheral blood common mitochondrial deletion (mtDNA(4977)) and mtDNA-CN on long-term major adverse cardiac events (MACEs) and all-cause mortality in a cohort of patients with coronary artery disease (CAD).
Prognostic value of mitochondrial DNA(4977) deletion and mitochondrial DNA copy number in patients with stable coronary artery disease
Vecoli Cecilia;Borghini Andrea;Mercuri Antonella;Carpeggiani Clara;Picano Eugenio;
2018
Abstract
Background and aims: Mitochondrial DNA copy number (mtDNA-CN) depletion has been recently associated with an increased cardiovascular risk. However, the integrity of mtDNA is another key aspect of the energy metabolism and mitochondrial function. We investigated the prognostic role of peripheral blood common mitochondrial deletion (mtDNA(4977)) and mtDNA-CN on long-term major adverse cardiac events (MACEs) and all-cause mortality in a cohort of patients with coronary artery disease (CAD).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
