Objective: We discuss the main factors that influence thenanocarriers colloidal stability and their interaction withbiological media during drug delivery applications. We alsodiscuss some strategies that can be developed in order toovercome the biological barriers, and for development of advanceddrug delivery systems.Methods: Small angle X-raysand Neutron Scattering,Dynamic Light Scattering, Raman spectroscopy, Z-potential,Scanning and Transmission Electron Microscopy.Results: We investigated the complex behaviour of some nanocarriers,including amphiphilic block copolymer, dendrimers,liposome, and shape amphiphiles composed of modifiedamphiphilic cyclodextrin, and their interaction with cellsand model bio-membranes.
Soft Interaction and Colloidal Stability of Nanocarriers in Drug Delivery Applications
Lombardo Domenico;Calandra Pietro;
2016
Abstract
Objective: We discuss the main factors that influence thenanocarriers colloidal stability and their interaction withbiological media during drug delivery applications. We alsodiscuss some strategies that can be developed in order toovercome the biological barriers, and for development of advanceddrug delivery systems.Methods: Small angle X-raysand Neutron Scattering,Dynamic Light Scattering, Raman spectroscopy, Z-potential,Scanning and Transmission Electron Microscopy.Results: We investigated the complex behaviour of some nanocarriers,including amphiphilic block copolymer, dendrimers,liposome, and shape amphiphiles composed of modifiedamphiphilic cyclodextrin, and their interaction with cellsand model bio-membranes.| File | Dimensione | Formato | |
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2016 nanomaterials con lombardo -.pdf
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