RET mutations are responsible for multiple endocrine neoplasia (MEN2A and MEN2B) and familial medullary thyroid carcinoma (FMTC). Sprouty family proteins (SPRY/SPRED) are inhibitors of signalling mediated by tyrosine-kinase receptors. As SPRY genes inhibit Ras-ERK-MAPK signalling and many aberrations in this pathway are most epitomized by cancer, we have hypothesized a possible role of this protein family in MEN2 and FMTC pathogenesis
Possible role of Sprouty-2 in Familial Medullary Thyroid Carcinoma Pathogenesis
Laura Frogheri;Stefania Casula;Mario Pirastu;
2010
Abstract
RET mutations are responsible for multiple endocrine neoplasia (MEN2A and MEN2B) and familial medullary thyroid carcinoma (FMTC). Sprouty family proteins (SPRY/SPRED) are inhibitors of signalling mediated by tyrosine-kinase receptors. As SPRY genes inhibit Ras-ERK-MAPK signalling and many aberrations in this pathway are most epitomized by cancer, we have hypothesized a possible role of this protein family in MEN2 and FMTC pathogenesisFile in questo prodotto:
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