The trifluoro analogue 1 of Casodex® was synthesized in racemic form, according to a strategy based on the use of trifluoropyruvate as a key starting material. This compound showed significant in vitro anti-proliferative activity on the human prostate cancer cell line LNCaP
Synthesis and in vitro anti-proliferative activity of racemic trifluoro-Casodex® (Bicalutamide)
Sani M;Viani F;Zanda M
2005
Abstract
The trifluoro analogue 1 of Casodex® was synthesized in racemic form, according to a strategy based on the use of trifluoropyruvate as a key starting material. This compound showed significant in vitro anti-proliferative activity on the human prostate cancer cell line LNCaPFile in questo prodotto:
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