Polyoxometalates (POMs) and peptides can be conjugated to yield novel bio-hybrids with potential application as nanodrugs. However, the observed POM-induced folding of the peptide prevents its availability towards biological targets. An Anderson-Evans POM was functionalized with a bombesin analog peptide and engineered by adding a tailored hydrophilic and anionic spacer between the two moieties, to make the targeting sequence more accessible and enable an unprecedented cancer cell recognition capability. This journal is
Enhancing the biological activity of polyoxometalate-peptide nano-fibrils by spacer design
Honisch Claudia;Ruzza Paolo
;
2021
Abstract
Polyoxometalates (POMs) and peptides can be conjugated to yield novel bio-hybrids with potential application as nanodrugs. However, the observed POM-induced folding of the peptide prevents its availability towards biological targets. An Anderson-Evans POM was functionalized with a bombesin analog peptide and engineered by adding a tailored hydrophilic and anionic spacer between the two moieties, to make the targeting sequence more accessible and enable an unprecedented cancer cell recognition capability. This journal isFile in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
2021_RSC-Adv.pdf
accesso aperto
Descrizione: Enhancing the biological activity of polyoxometalate–peptide nano-fibrils by spacer design
Tipologia:
Versione Editoriale (PDF)
Licenza:
Creative commons
Dimensione
667.64 kB
Formato
Adobe PDF
|
667.64 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
