INTRODUCTION: Paraoxonase 2 (PON2) is a calcium-dependent transmembrane lactonase which is ubiquitously expressed in a variety of tissues including kidney. In addition to the lactonase activity, PON2 also exhibits anti-oxidative and anti-atherosclerotic properties. Recent RNA-seq analysis on rat kidney demonstrated thatPON2 mRNA has been detected in several nephron segments including connecting tubule and cortical collecting duct, in which ENaC is also expressed. Here we investigated the regulation of PON2 in an experimental model of hypertension and different condition that modulates aldosterone-sensitive distal nephron. (18) (PDF) SP038RENAL PARAOXONASE 2 REGULATION IN HYPERTENSIVE ADD-1 MUTANT RATS. Available from: https://www.researchgate.net/publication/333771918_SP038RENAL_PARAOXONASE_2_REGULATION_IN_HYPERTENSIVE_ADD-1_MUTANT_RATS [accessed Dec 20 2021].
RENAL PARAOXONASE 2 REGULATION IN HYPERTENSIVE ADD-1 MUTANT RATS
Giuseppe Manco;
2019
Abstract
INTRODUCTION: Paraoxonase 2 (PON2) is a calcium-dependent transmembrane lactonase which is ubiquitously expressed in a variety of tissues including kidney. In addition to the lactonase activity, PON2 also exhibits anti-oxidative and anti-atherosclerotic properties. Recent RNA-seq analysis on rat kidney demonstrated thatPON2 mRNA has been detected in several nephron segments including connecting tubule and cortical collecting duct, in which ENaC is also expressed. Here we investigated the regulation of PON2 in an experimental model of hypertension and different condition that modulates aldosterone-sensitive distal nephron. (18) (PDF) SP038RENAL PARAOXONASE 2 REGULATION IN HYPERTENSIVE ADD-1 MUTANT RATS. Available from: https://www.researchgate.net/publication/333771918_SP038RENAL_PARAOXONASE_2_REGULATION_IN_HYPERTENSIVE_ADD-1_MUTANT_RATS [accessed Dec 20 2021].I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
