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The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at . G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors
Alexander Stephen P H;Christopoulos Arthur;Davenport Anthony P;Kelly Eamonn;Mathie Alistair;Peters John A;Veale Emma L;Armstrong Jane F;Faccenda Elena;Harding Simon D;Pawson Adam J;Southan Christopher;Davies Jamie A;Abbracchio Maria Pia;Alexander Wayne;Alhosaini Khaled;Baeck Magnus;Barnes Nicholas M;Bathgate Ross;Beaulieu JeanMartin;Bernstein Kenneth E;Bettler Bernhard;Birdsall Nigel J M;Blaho Victoria;Boulay Francois;Bousquet Corinne;BraeunerOsborne Hans;Burnstock Geoffrey;Calo Girolamo;Castano Justo P;Catt KevinJ;Ceruti Stefania;Chazot Paul;Chiang Nan;Chini Bice;Chun Jerold;Cianciulli Antonia;Civelli Olivier;Clapp Lucie H;Couture Rejean;Csaba Zsolt;Dahlgren Claes;Dent Gordon;Singh Khuraijam Dhanachandra;Douglas Steven D;Dournaud Pascal;Eguchi Satoru;Escher Emanuel;Filardo Edward J;Fong Tung;Fumagalli Marta;Gainetdinov Raul R;de Gasparo Marc;Gerard Craig;Gershengorn Marvin;Gobeil Fernand;Goodfriend Theodore L;Goudet Cyril;Gregory Karen J;Gundlach Andrew L;Hamann Joerg;Hanson Julien;Hauger Richard L;Hay Debbie L;Heinemann Akos;Hollenberg Morley D;Holliday Nicholas D;Horiuchi Mastgugu;Hoyer Daniel;Hunyady Laszlo;Husain Ahsan;IJzerman Adriaan P;Inagami Tadashi;Jacobson Kenneth A;Jensen Robert T;Jockers Ralf;Jonnalagadda Deepa;Karnik Sadashiva;Kaupmann Klemens;Kemp Jacqueline;Kennedy Charles;Kihara Yasuyuki;Kitazawa Takio;Kozielewicz Pawel;Kreienkamp HansJuergen;Kukkonen Jyrki P;Langenhan Tobias;Leach Katie;Lecca Davide;Lee John D;Leeman Susan E;Leprince Jerome;Li Xaria X;Williams Tom Lloyd;Lolait Stephen J;Lupp Amelie;Macrae Robyn;Maguire Janet;Mazella Jean;McArdle Craig A;Melmed Shlomo;Michel Martin C;Miller Laurence J;Mitolo Vincenzo;Mouillac Bernard;Mueller Christa E;Murphy Philip;Nahon JeanLouis;Ngo Tony;Norel Xavier;Nyimanu Duuamene;Ocarroll AnneMarie;Offermanns Stefan;Panaro Maria Antonietta;Parmentier Marc;Pertwee Roger G;Pin JeanPhilippe;Prossnitz Eric R;Quinn Mark;Ramachandran Rithwik;Ray Manisha;Reinscheid Rainer K;Rondard Philippe;Rovati G Enrico;Ruzza Chiara;Sanger Gareth J;Schoeneberg Torsten;Schulte Gunnar;Schulz Stefan;Segaloff Deborah L;Serhan Charles N;Stoddart Leigh A;Sugimoto Yukihiko;Summers Roger;Tan Valerie P;Thal David;Thomas Walter Wally;Timmermans PieterB M W M;Tirupula Kalyan;Tulipano Giovanni;Unal Hamiyet;Unger Thomas;Valant Celine;Vanderheyden Patrick;Vaudry David;Vaudry Hubert;Vilardaga JeanPierre;Walker Christopher S;Wang Ji Ming;Ward Donald T;Wester HansJuergen;Willars Gary B;Woodruff Trent M;Yao Chengcan;Ye Richard D
2021
Abstract
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at . G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/445572
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simulazione ASN
Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande.
La presente simulazione è stata realizzata sulla base delle specifiche raccolte sul tavolo ER del Focus Group IRIS coordinato dall'Università di Modena e Reggio Emilia e delle regole riportate nel DM 589/2018 e allegata Tabella A. Cineca, l'Università di Modena e Reggio Emilia e il Focus Group IRIS non si assumono alcuna responsabilità in merito all’uso che il diretto interessato o terzi faranno della simulazione. Si specifica inoltre che la simulazione contiene calcoli effettuati con dati e algoritmi di pubblico dominio e deve quindi essere considerata come un mero ausilio al calcolo svolgibile manualmente o con strumenti equivalenti.