Different types of fused-silica capillaries of 75 mm inside diameter (ID) were packed, namely type A and B, and evaluated for the direct resolution of racemates of several basic compounds by enantioselective capillary electrochromatography (e-CEC). Type A was packed with a chiral stationary phase (CSP) containing teicoplanin (TE) mixed with silica microparticles (3:1 w/w) while type B contained only the TE-CSP. In both cases, particles of different sizes (3.5 and 5 mm ID) were employed. A polar-organic mobile phase containing methanol-acetonitrile (6040% v/v and 0.05% w/v ammonium acetate was used. Several b-blockers (alprenolol, oxprenolol, metoprolol, pindolol, salbutamol, propranolol, atenolol, acebutolol) were baseline-enantioresolved with both capillary types, in very short times.
Evaluation of teicoplanin chiral stationary phases of 3.5 and 5 mm inside diameter silica microparticles by polar-organicmode capillary electrochromatography
Fanali S;
2003
Abstract
Different types of fused-silica capillaries of 75 mm inside diameter (ID) were packed, namely type A and B, and evaluated for the direct resolution of racemates of several basic compounds by enantioselective capillary electrochromatography (e-CEC). Type A was packed with a chiral stationary phase (CSP) containing teicoplanin (TE) mixed with silica microparticles (3:1 w/w) while type B contained only the TE-CSP. In both cases, particles of different sizes (3.5 and 5 mm ID) were employed. A polar-organic mobile phase containing methanol-acetonitrile (6040% v/v and 0.05% w/v ammonium acetate was used. Several b-blockers (alprenolol, oxprenolol, metoprolol, pindolol, salbutamol, propranolol, atenolol, acebutolol) were baseline-enantioresolved with both capillary types, in very short times.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
