The Relevance of Metabotrophic Factors in Pathobiology and Therapy of Obesity and Related Diseases.

Currently, the most widespread global ailment is not COVID-19 or any2 other such devastating infectious diseases. In fact, obesity has been recognized3 as a prime risk in the development of cardiometabolic diseases (CMD), neurode-4 generative diseases (NDD) and cancer and their morbidity and mortality signa-5 ture. The pathobiology and therapy of obesity and related diseases are immensely6 complex at the cellular and molecular levels. This scenario raises the question of7 how such a complexity may be grappled in a more tangible manner. Since 2003,8 we have been thinking "what nobody has yet thought about that which everybody9 sees", namely, metabotrophic factors (MTF or metabotrophins, metabokines). They10 include mainly (i) the neurotrophins nerve growth factor (NGF) and brain-derived11 neurotrophic factor (BDNF), and (ii) the adipomyokines adiponectin, irisin, BDNF,12 fibroblast growth factor-21 alike as adipose- and skeletal muscle-derived signaling