Asymmetrical heterocomplexes containing a terminal technetium-nitrogen multiple bond coordinated to one diphosphine ligand (PNP) and one dithiocarbamate ligand (DBODC), were obtained through a sinple two-step procedure under controlled conditions. The resulting complexes [99mTc(N) (PNP)(DBODC)]+ are monocationic, and possess a distorted square-pyramidal geometry where the Tc=N multiple bond occupies an apical position and the diphosphine and dithiocarbamate ligands span the residual four coordination positions on the basal plane through the two phosphorous atoms and the two sulfur atoms, respectively. Biodistribution data in rats demonstrated that these complexes were rapidly extracted by the myocardium, and retained in this region for a prolonged time. After a few minutes post-injection, lung uptake becomes negligible, and liver washout was extremely rapid and quantitative.
A class of asymmetrical nitrido 99mTc heterocomplexes as heart imaging agents with improved biological properties
Bolzati C;Refosco F;Tisato F;
2002
Abstract
Asymmetrical heterocomplexes containing a terminal technetium-nitrogen multiple bond coordinated to one diphosphine ligand (PNP) and one dithiocarbamate ligand (DBODC), were obtained through a sinple two-step procedure under controlled conditions. The resulting complexes [99mTc(N) (PNP)(DBODC)]+ are monocationic, and possess a distorted square-pyramidal geometry where the Tc=N multiple bond occupies an apical position and the diphosphine and dithiocarbamate ligands span the residual four coordination positions on the basal plane through the two phosphorous atoms and the two sulfur atoms, respectively. Biodistribution data in rats demonstrated that these complexes were rapidly extracted by the myocardium, and retained in this region for a prolonged time. After a few minutes post-injection, lung uptake becomes negligible, and liver washout was extremely rapid and quantitative.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
