Gamma-delta T cells and their clinical application in colon cancer

In recent years, research has focused on colorectal cancer to implement modern treatment approaches to improve patient survival. In this new era, ?? T cells constitute a new and promising candidate to treat many types of cancer because of their potent killing activity and their ability to recognize tumor antigens independently of HLA molecules. Here, we focus on the roles that ?? T cells play in antitumor immunity, especially in colorectal cancer. Furthermore, we provide an overview of small-scale clinical trials in patients with colorectal cancer employing either in vivo activation or adoptive transfer of ex vivo expanded ?? T cells and suggest possible combinatorial approaches to treat colon cancer.