Reaction of (1,3,5-triaza-7-phosphaadamantane-6-yl)lithium (1; PTA-Li), synthesized in high yield and purity, with p-(dimethylamino)benzaldehyde gave the novel water soluble ?-phosphino alcohol (40-(dimethylamino)phenyl) (1,3,5-triaza-7-phosphatricyclo[3.3.1.1]dec-6-yl)methanol (2; PZA-NMe2). The oxide O=PZA-NMe2 (3) and sulfide S=PZA-NMe2 (4) were also obtained. Ir(I) complexes of (SR,RS)-PZA-NMe2 and the analogue phenyl(1,3,5-triaza-7-phosphatricyclo[3.3.1.1]dec-6-yl)methanol (PZA) were obtained and used as precatalysts for the hydrogenation of a,?-unsaturated aldehydes and ketones and acetophenone using different mild reduction protocols. The X-ray crystal structure of the SR,RS diastereoisomer of PZA-NMe2 was also obtained and is described herein.
Iridium(I) Complexes of Upper Rim Functionalized PTA Derivatives. Synthesis, Characterization and Use in Catalytic Hydrogenations (PTA = 1,3,5-triaza-7-phosphaadamantane)
Guerriero Antonella;Ienco Andrea;Peruzzini Maurizio;Reginato Gianna;Gonsalvi Luca
2011
Abstract
Reaction of (1,3,5-triaza-7-phosphaadamantane-6-yl)lithium (1; PTA-Li), synthesized in high yield and purity, with p-(dimethylamino)benzaldehyde gave the novel water soluble ?-phosphino alcohol (40-(dimethylamino)phenyl) (1,3,5-triaza-7-phosphatricyclo[3.3.1.1]dec-6-yl)methanol (2; PZA-NMe2). The oxide O=PZA-NMe2 (3) and sulfide S=PZA-NMe2 (4) were also obtained. Ir(I) complexes of (SR,RS)-PZA-NMe2 and the analogue phenyl(1,3,5-triaza-7-phosphatricyclo[3.3.1.1]dec-6-yl)methanol (PZA) were obtained and used as precatalysts for the hydrogenation of a,?-unsaturated aldehydes and ketones and acetophenone using different mild reduction protocols. The X-ray crystal structure of the SR,RS diastereoisomer of PZA-NMe2 was also obtained and is described herein.File | Dimensione | Formato | |
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Descrizione: Iridium(I) Complexes of Upper Rim Functionalized PTA Derivatives.
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