The RNA-world hypothesis has generated much interest in finding a plausible prebiotic route to RNA. The abiotic synthesis of the purine nucleobases is of particular interest, given proposals that early proto-RNA polymers might have contained only purine nucleobases. Formamide is attractive as a potential prebiotic starting material for the nucleobases; it contains the four required elements (C, H, O, N) and stands out because of its likely prebiotic availability, relative stability, versatile reactivity, and low volatility compared to water.
Guanine, Adenine, and Hypoxanthine Production in UV-Irradiated Formamide Solutions: Relaxation of the Requirements for Prebiotic Purine Nucleobase Formation
E Di Mauro;
2010
Abstract
The RNA-world hypothesis has generated much interest in finding a plausible prebiotic route to RNA. The abiotic synthesis of the purine nucleobases is of particular interest, given proposals that early proto-RNA polymers might have contained only purine nucleobases. Formamide is attractive as a potential prebiotic starting material for the nucleobases; it contains the four required elements (C, H, O, N) and stands out because of its likely prebiotic availability, relative stability, versatile reactivity, and low volatility compared to water.File in questo prodotto:
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